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Marco accepted to the DFG Heisenberg Programme

Marco accepted to the DFG Heisenberg Programme

The German Research Foundation (DFG) awarded the prestigious Heisenberg prize to Marco to promote his research on ubiquitination, in particular investigating cross-talk with cellular signalling mediated by kinases.

“We are humbled by this honour and deeply grateful for the support of the DFG”

New Annual Review on PUBs

New Annual Review on PUBs

We just published an Annual Review in Plant Biology on ” The Evolution and Functions of Plant U-Box Proteins: From Protein Quality Control to Signaling” were we explore the evolution of U-box proteins in the plant lineage all the way to structural details of E3 function.

Please have a look here

#Proteostasis #U-box #evolution #structure #plantsci #PUB #plants #ubiquitin #E3ligases #ubiquitinligases #E2s #ubiquitinconjugatingenzymes #review #stressbiology #stressedplants #immunity #droughtstress #crops

Carla is part of CORA – Leadership training

Carla is part of CORA – Leadership training

We are very proud of Carla who was accepted in the new round of the CORA Coaching Program at the University of Freiburg!
Vice-President Prof. Dr. Sylvia Paletschek opened the Kick Off event on March 11th 🚀
CORA is a career advancement program focused on preparing female scientists for future leadership positions. GO Carla!

#femaleleadership #leadership #coachingprogram #getthefutureyouwant #breakthebias #Postdocs #genderequality #university #womeninacademia #womeninscience #womenintech #CoraUniFreiburg #leaders

Lab outing

Lab outing

It has been a while since we last had an outing. We went bowling this time and had a great time. The boss was on a row!

#labouting #bowlingscientists

New Cooperation Pub with the Djamei Lab @effectomics

New Cooperation Pub with the Djamei Lab @effectomics

The Pleiades are a cluster of fungal effectors that inhibit host defenses

https://journals.plos.org/plospathogens/article?id=10.1371/journal.ppat.1009641

Biotrophic plant pathogens secrete effector proteins to manipulate the host physiology. Effectors suppress defenses and induce an environment favorable to disease development. In this paper we describe the functional characterization of the pleiades, a cluster of ten effector genes. Merope1, which is encoded in the Pleiades cluster, targets and promotes the auto-ubiquitination activity of RFI2, a conserved family of E3 ligases that regulates the production of PAMP-triggered ROS burst in plants.

Tansley insight on ubiquitin signalling is now out!

Tansley insight on ubiquitin signalling is now out!

Ubiquitin signalling: controlling the message of surface immune receptors

Microbial attack is first detected by immune receptors located at the plasma membrane. Their activation triggers a plethora of signalling cascades that culminate in the immune response. Ubiquitin and ubiquitin-like protein modifiers play key roles in controlling signalling amplitude and intensity, as well as in buffering proteome imbalances caused by pathogen attack. Here I highlight some of the important advances in the field, which are starting to reveal an intertwined and complex signalling circuitry, which regulates cellular dynamics and protein degradation to maintain homeostasis.