Lab outing
It has been a while since we last had an outing. We went bowling this time and had a great time. The boss was on a row!
#labouting #bowlingscientists
Farewell Bushra
We bid farewell to Bushra who will move the Spoel Lab @SpoelLab in Edinburgh, but will stick to ubiquitination.
We wish you the best of luck!
New Cooperation Pub with the Djamei Lab @effectomics
The Pleiades are a cluster of fungal effectors that inhibit host defenses
https://journals.plos.org/plospathogens/article?id=10.1371/journal.ppat.1009641
Biotrophic plant pathogens secrete effector proteins to manipulate the host physiology. Effectors suppress defenses and induce an environment favorable to disease development. In this paper we describe the functional characterization of the pleiades, a cluster of ten effector genes. Merope1, which is encoded in the Pleiades cluster, targets and promotes the auto-ubiquitination activity of RFI2, a conserved family of E3 ligases that regulates the production of PAMP-triggered ROS burst in plants.